Fully cleanse the face or affected area and pat dry. Peel off a daytime or nighttime patch with clean hands and press gently until it sticks. Leave it alone so it doesn't fall off. Using patches without clean hands and face can trap more bacteria under the patch and cause bigger issues. These patches will not stick well to oily or wet skin.The flesh color patches conceal spots to keep you from picking them or are tempted to pop, and offer protection from external pollution which can further exasperate flare-ups.Use for up to 8 hours, remove once they turn white, clean your hands and face, and replace with a new patch for stubborn zits. These greatly reduce redness, pain, and even swelling fairly quickly. However, these may not work for everyone. I have sensitive skin, and these did not bother me one bit.Acceptable quality, discreet by day, and set it and forget it at bedtime. Easy-to-follow instructions are included.